Drotaverine hydrochloride

CAS No. 985-12-6

Drotaverine hydrochloride ( —— )

Catalog No. M22762 CAS No. 985-12-6

Drotaverine hydrochloride is a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor,and is an antispasmodic drug, used to enhance cervical dilation during childbirth.?

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 65 In Stock
25MG 125 In Stock
50MG 237 In Stock
100MG 354 In Stock
500MG 845 In Stock
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Biological Information

  • Product Name
    Drotaverine hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Drotaverine hydrochloride is a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor,and is an antispasmodic drug, used to enhance cervical dilation during childbirth.?
  • Description
    Drotaverine hydrochloride is a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor,and is an antispasmodic drug, used to enhance cervical dilation during childbirth.?Drotaverine hydrochloride?is structurally related to papaverine?drotaverine not only relaxed the precontracted tracheal preparations but also decreased mediator-induced contraction.?These effects of drotaverine were concentration dependent, with a significantly higher potency on the KCl-induced response, than on either the histamine or methacholine induced one.?A similar result was noted for nifedipine.?The PDE inhibitor, theophylline, also relaxed the precontracted preparations but was ineffective on the mediator-induced contraction in a physiologically relevant concentration range.
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    PDE
  • Recptor
    PDE4
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    985-12-6
  • Formula Weight
    433.97
  • Molecular Formula
    C24H32ClNO4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Cl.CCOc1ccc(cc1OCC)CC2=NCCc3cc(OCC)c(OCC)cc23
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Patai, Zoltán, Guttman, András, Mikus E . Assessment of the Airway Smooth Muscle Relaxant Effect of Drotaverine[J]. Pharmacology, 2018:163.
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